FACTORS AFFECTING OUTCOME IN ASSISTED REPRODUCTIVE TECHNOLOGY

  • Alrashedy M. I
  • Ahmed M. A. M
  • Mubark A. A
Keywords: ICSI , Outcome , pregnancy rate , Infertility.

Abstract

Background:
Different success rate of
Intracytoplasmic Sperm injection
(ICSI) has been observed in various
causes of infertility. In this study, we
evaluated factors affecting ICSI
outcome in different causes of
infertility. We also aimed to examine
parameters that might predict the
pregnancy success rate following.

Materials and Methods:
This is a case control study included 94
infertile women referred to Qena University
Hospital at the assisted reproductive
technology unit from review of the patients
medical records throughout the period of
two years from June 2016 to June 2018. We
assigned two groups including pregnant
who are control group (n=41) and nonpregnant who are case group (n=53), while
all participants underwent ICSI cycles. All
statistics were performed by SPSS program.
Statistical Analysis was carried out using
Chi-square and t test.

Results:
The overall pregnancy rate in our study
was 43.6 % (n=41). There were
statistically significant difference in
maternal age , BMI, period of infertility,
serum luteinizing hormone (LH)
folliclestimulating hormone (FSH),
paternal age , serum AMH, quality of
embryo and number of ova retrived
between the pregnant and the nonpregnant groups (p<0.05). However, There were no
significant differences between two groups
in the serum concentrations thyroidstimulating hormone (TSH), and serum
prolactin (PRL) , previous pregnancy and
previous trials of ICSI. We found no
association between different causes of
infertility and the outcomes .

Conclusion:
Our results indicate that ART in an effective
option in couples with different causes of
infertility. There are many variable that affect
ART outcome. These variables should be
integrated into a statistical model to allow the
prediction for the chance of pregnancy
following ICSI cycles. It is required that each
infertility center gather enough information
about the causes of infertility in order to
provide more information and better
assistance to patients. Therefore, we suggest
that physicians prepare adequate training and
required information regarding these
procedures for infertile couples in order to
improve their knowledge

Published
2019-07-01
Section
Articles