Serum level of 25 hydroxy Vitamin D and Interleukin 17 in patients with Lichen Planus
Objectives: The aim of this study is to detect serum level of vitamin D and IL17 in patients with lichen planus
(LP) and to determine the relationship between vitamin D and IL-17 in the disease activity of LP.
Study design: Case control study.
Setting: Department of Dermatology, Venereology and Andrology, Qena university hospital, Qena, Egypt
Patients: 30 patients clinically diagnosed as LP who were fulfilling the inclusion criteria and 20 healthy subjects
were collected from the out-patient clinic of dermatology, venerology and andrology department, Qena University
Hospitals. An informed consent was obtained from all participants.
Main outcome measures: (1) Primary outcome: detection of serum level of vitamin D and IL17 in patients with
LP using special vitamin D and IL17 kites by ELIZA. (2) Secondary outcome: determine the relationship between
vitamin D and IL-17 in the disease activity of LP.
Results: Our results showed that mean level of Vit D between patients and controls was nonsignificant (P=
0.321), on the other hand, mean level of IL17 between patients and controls was significant (P=0.000) and there
was no relation between vitamin D and IL-17 in the disease activity of LP.
Conclusion: We concluded that serum level of IL-17 is significantly high in patients with LP, but there is no
significant relationship between vitamin D and IL17 in activity of LP.